Human
인간 대상 연구
건강 자원자, 비만 환자, 섭식장애환자를 대상으로 전자약 (경두개 전기자극술 TES, tDCS), fMRI, digital phenotyping, 디지털치료제 (Digital therapeutics), 인지 과제, 설문지, 섭식행동평가 방법을 사용하여, 섭식행동, 섭식심리, 비만, 음식중독의 기전과 치료 방법을 연구합니다. 또한 노인 근감소성 비만 임상 연구와 통합 노쇠중재에 대한 기술력을 바탕으로 창업화를 개발 중에 있습니다.
￭ 연구분야
- 신체 대사 조절에서 뇌중추의 역할 규명
- 섭식행동 표현형과 뇌 중추의 관계 규명
- 비만/당뇨/섭식장애 등 대사성 질환 발병원인 규명 및 치료방법 개발
- 디지털 치료제, 전자약을 통한 효과적 치료 방법 개발
1) Neuroimaging: functional MRI (음식 사진 자극 뇌반응, resting state), 구조영상 MRI/CT/PET
2) 디지털 헬스케어: 비만/당뇨병/섭식장애 등 대사성 질환 관련 디지털 표현형 평가 및 디지털 치료제
3) 인지과제 (computerized task): 음식 사진/언어 반응 등 다양한 인지심리과제를 통한 대사성 질환 관련 심리/인지 평가 및 치료
4) 생활습관치료 중재 연구: 식습관, 운동습관, 일상/감정/동기 개선을 위한 코칭/디지털 치료제
5) 전자약 (Electroceuticals) : 경두개 전기자극술 TES (tDCS)
6) 약제 연구: 대사질환 치료 약제의 효과 및 기전 연구
7) 설문지: 비만 등 대사질환 관련 심리, 행동, 인지, 감정, 질환 등 평가
8) 역학 연구: 대사성 질환 관련 역학 연구
본 연구실의 관련 연구 성과 논문들
뇌영상(Neuroimaging)
Clinical Implication of Individually Tailored Segmentation Method for Distorted Hypothalamus in Craniopharyngioma
AR Hong, M Lee, JH Lee, JH Kim, YH Kim, HJ Choi
Frontiers in Endocrinology, 2021
https://www.frontiersin.org/articles/10.3389/fendo.2021.763523/full
Glucagon-like peptide-1 receptor agonist differentially affects brain activation in response to visual food cues in lean and obese individuals with type 2 diabetes mellitus
JH Bae, HJ Choi, KIK Cho, LK Kim, JS Kwon, YM Cho
Diabetes & metabolism journal 44 (2), 248-259, 2020
https://www.e-dmj.org/journal/view.php?doi=10.4093/dmj.2019.0018
디지털 헬스케어/생활습관치료 중재 연구
Machine Learning Analysis to Identify Digital Behavioral Phenotypes for Engagement and Health Outcome Efficacy of an mHealth Intervention for Obesity: Randomized Controlled Trial
M Kim, J Yang, WY Ahn, HJ Choi
Journal of medical Internet research 23 (6), e27218, 2021
https://www.jmir.org/2021/6/e27218/
Digital Therapeutics for Obesity and Eating-Related Problems
M Kim, HJ Choi
Endocrinology and Metabolism 36 (2), 220, 2021
https://www.e-enm.org/journal/view.php?doi=10.3803/EnM.2021.107
Clinical efficacy and plausibility of a smartphone‐based integrated online real‐time diabetes care system via glucose and diet data management: a pilot study
EJ Ku, JI Park, HJ Jeon, T Oh, HJ Choi
Internal medicine journal 50 (12), 1524-1532, 2020
https://onlinelibrary.wiley.com/doi/10.1111/imj.14738
Healthy Eating Behavior Change with Psychological Features and Insulin Resistance: Buffet and Food Diary App Analysis
M Kim, S Park, C Kim, HJ Choi, 2021
https://www.researchsquare.com/article/rs-140427/v1
Multidimensional cognitive behavioral therapy for obesity applied by psychologists using a digital platform: open-label randomized controlled trial
M Kim, Y Kim, Y Go, S Lee, M Na, Y Lee, S Choi, HJ Choi
JMIR mHealth and uHealth 8 (4), e14817, 2020
https://mhealth.jmir.org/2020/4/e14817
역학 연구
Mental health of people with distorted body weight perception using medicinal remedies: A representative study
M Kim, S Kim, W Kim, HJ Choi
International Journal of Clinical and Health Psychology 21 (2), 100224, 2021
https://www.sciencedirect.com/science/article/pii/S1697260021000053
약제 연구
Clinical effectiveness of liraglutide on weight loss in South Koreans: First real-world retrospective data on Saxenda in Asia
JS Park, J Kwon, HJ Choi, C Lee
Medicine 100 (2), 2021
Atypical Antipsychotics are Disproportionately Associated with Patients Reporting Increased Eating Drives
SY Yum, SK Yum, HJ Choi
Psychiatry Investigation 18 (3), 266, 2021
https://www.psychiatryinvestigation.org/journal/view.php?doi=10.30773/pi.2020.0431